Initiating Long-Term Coverage, Harnessing The Power of The Innate (Natural) Immune System

Update August 27th, 2019 – A must see video on (NASDAQ: INMB)

Update August 13th, 2019- INmune Bio Reports Second Quarter 2019 Financial Results and Provides Shareholder Update –

August 5th, 2019 update – (NASDAQ: INMB) phase 1 data out this morning, click here-

This technology was only theoretical a few years ago and a concept with extraordinary potential.

Our human immune system is amazing.

Through a series of steps called the immune response, the immune system attacks organisms and substances that invade body systems and cause disease.

Sadly, our immune system isn’t designed to cure every disease that attacks our bodies. Diseases such as Alzheimer’s and Cancer aren’t included our body’s innate immune system design.

But what if our innate immune system could be reprogrammed to conquer even those insidious and sometimes deadly diseases.

What if our own bodies could fight Cancer and Alzheimer’s without having to subject ourselves to harsh therapeutic substances like chemo therapy.

Wouldn’t it be great if someone was working on that reprogramming of the natural immune system?

Well, someone is.

INmune Bio Inc. (NASDAQ: INMB) is a clinical stage biotechnology company that is developing new immunotherapies that reprogram a patient’s innate immune system to allow the immune system to fight cancer and Alzheimer’s Disease (AD).

The INMB development programs include INKmune, which focuses on treating women with relapse refractory ovarian carcinoma; INB03 that treats patients with advanced cancers with elevated biomarkers of inflammation, including elevated levels of myeloid derived suppressor cells in their blood; and XPro1595 for the treatment of Alzheimer’s disease.

Our bodies have two types of immunity:

Innate immunity

Innate immunity refers to defense mechanisms that come into play immediately or within hours of an antigen’s appearance in the body. These mechanisms include physical barriers such as skin, chemicals in the blood, and immune system cells that attack foreign cells in the body. We are born with innate, or natural, immunity essentially made up of barriers to keep viruses, bacteria, parasites, and other foreign particles out of your body or limit their ability to spread.

Adaptive immunity

Adaptive immunity refers to antigen-specific immune response. The adaptive immune response is more complex than the innate. The antigen first must be processed and recognized. Once an antigen has been recognized, the adaptive immune system creates an army of immune cells specifically designed to attack that antigen. For example, once you have measles you are immune from it forever, but not from other viruses such as mumps or chickenpox.

Most immune-oncology companies are working to develop therapies that work with the adaptive immunity system, but INmune is working with the innate immunity system utilizing a targeted biomarker response.

Let’s be clear about what INmune is working toward. They are developing compounds designed to reprogram our natural immune system to defeat cells beyond viruses, parasites and bacteria, such as cancer and Alzheimer’s. Think of the implications and potentials.

The company’s platforms target the overlooked elements of immunology:

• Innate immune system

• “Resistance” immunology of the Tumor Microenvironment

• Neuroinflammation is a cause of Alzheimer’s disease

We will talk more below about the clinical trials, and the company’s progress and potential. If you are reading this, you are likely an investor familiar with many biopharma and biotech clinical stage companies. You are probably familiar with companies that are working on therapies to treat cancer and Alzheimer’s with new drugs, but how many are working on therapies to bolster our own natural immune systems to treat the same diseases?

INmune is still under the radar of many investors as they just completed their IPO in February of 2019.

At the end of June, Dr. Mark Lowdell, Chief Scientific Officer and co-founder at INmune Bio, co-authored an article titled: “Tumor- and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures,” summarizing the different effects between NK (natural killer) cell activation in response to tumor cells and cytokine-mediated activation.

The data cited in the article confirm that the primed NK cells generated by INB16 stimulation upregulate genes, which are crucial to NK-mediated killing of patients’ cancer cells.

Also, in June, R.J. Tesi, M.D., the company’s co-founder and CEO, presented at the Maxim Group’s conference on Alzheimer’s disease. During the conference, titled “Alzheimer’s Disease – What’s Next? Treating Alzheimer’s in a Post-Amyloid World,” Dr. Tesi discussed INmune Bio’s novel approach to treating Alzheimer’s with XPro1595, a second-generation selective inhibitor of soluble TNF (tumor necrosis factor) to combat neuroinflammation and microglial activation.

The graphic below discusses the immune system and the clinical trials for the INMB pipeline. More importantly to you, the investor, it highlights the upcoming potential catalysts associated with their products.

For those who want a more detailed, technical picture of the INMB products, how they work and what data has been generated from studies and clinical trials; we have provided the link below to a full presentation:

In order to advance XPro1595 in the treatment of AD, INmune was recently awarded a $1 million grant from the Alzheimer’s Association.

The grant will support a biomarker-directed Phase 1 clinical trial in 18 patients with mild-to-moderate AD. XPro1595 will be administered subcutaneously once a week for three months and biomarkers of inflammation will be assessed at 0, 6, and 12 weeks.

Market potential for the INMB product pipeline:

• XPro1595 – Alzheimer’s/dementia market

5.8 M patients in US

2019 estimated cost to care for US AD patients $280 billion

• INKmune – Cancer residual disease market

1,735,350 new cases and 609,640 people will die

Initial targets: Ovarian Cancer and High Risk MDS

• INB03 – Resistance to Checkpoint Inhibitors market

CPI’s work 27% of patients. CPI 2025 estimated market size $56 billion

INB03 in combination with CPI’s should increase the number of patients sensitive to CPIs.

Initial targets: Melanoma and Renal Cell Cancer

Would you be surprised to hear that insiders have spent $770,000 buying up company shares in the past two months and they own 63% of the outstanding shares?

The public float is only 2.98 million shares

INmune has no debt

Date               Brokerage                Action          Rating             Price Target

6/10/2019    Maxim Group         Set Target   Buy                  $13.00

Can the work being done at INMB be successful enough to bring to market? Preliminary data shows that success is possible. Upcoming clinical trials will define the future for INmune and any positive data from those clinical trials could be strong catalysts for the company’s value. Today they are working toward immunity from Alzheimer’s and certain oncology indications. Who knows where success against those diseases could lead the company?

The work being done at INMB is not only important to the advancement of good health in humans, the market potential for the company’s product pipeline is very attractive. INMB seems like it could be a ground floor investment opportunity in cutting edge medical technology.

Stay tuned for more on INMB coming soon,

The Traders News Group


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