Stem Cell Collaboration Results Push Cellect Biotechnology Shares Higher, Full Analysis

Cellect Biotechnology Ltd. (NASDAQ: APOP) is a biotechnology company, focused on developing technologies for the functional selection of stem cells in the field of regenerative medicine and stem cell therapies in Israel.

March 11, 2019. Cellect Biotechnology, a developer of a novel stem cell production technology, today announced positive preliminary results from its collaboration with Cell2in, a privately-held South Korean company focused on improving the quality of stem cells. Results of this third-party study further validate that Cellect’s Apograft™ technology significantly improves both proliferation and functional capabilities of hematopoietic (HSC) and mesenchymal (MSC) stem cells originating from bone marrow, peripheral blood, umbilical cord, and adipose tissue.

Preliminary Results Include:

  • Higher degree of stemness (both in Cell2in and standard assays) maintained through repeated expansions of bone marrow and umbilical cord derived mesenchymal stem cells
  • Improved expansion of adipose derived mesenchymal stem cells in early and late passages
  • Significantly increased stemness of hematopoietic stem cells within two hours of the ApoGraft™ process

According to the company CEO, “The data, which has now been validated through a third-party corporate collaboration, demonstrates that Cellect’s ApoGraft™ technology enables improved quality stem cell production at a lower cost by providing a platform technology aimed at benefiting multiple stem cell therapy products,” commented Shai Yarkoni, Cellect’s Chief Executive Officer. “Together with our clinical data of allogeneic bone HSC (bone marrow) transplantation, this new program further supports the significance of the ApoGraft™ technology to all allogenic cell therapy. This is particularly relevant for MSCs, where the industry is moving towards off-the-shelf therapies requiring much larger expansions and represents a sizeable market opportunity for Cellect.”


Cellect Biotechnology Ltd., a biotechnology company, focuses on developing technologies for the functional selection of stem cells in the field of regenerative medicine and stem cell therapies in Israel. It is developing the Apotainer selection kit, a shelf stem cell selection kit, based on its Powered by Cellect technology platform for allogeneic hematopoietic stem cell transplantation procedures for patients suffering from hematological malignancies. Cellect Biotechnology Ltd. has a collaboration with the Washington University in determining the safety and tolerability in Phase I/II study using ApoGraft for bone marrow transplantations in the United States. The company was founded in 2011 and is headquartered in Kfar Saba, Israel.

Financial data

Third Quarter 2018 Financial Results:

Research and development (R&D) expenses for the third quarter of 2018 were $1.13 million, compared to $0.69 million in the second quarter of 2018 and $0.79 million in the third quarter of 2017. The increase in the third quarter of 2018 as compared to the second quarter of 2018 was primarily due to increased expenses related to the Company’s ongoing clinical trial and product development expenses.

General and administrative (G&A) expenses for the third quarter of 2018 were $1.08 million, compared to $1.00 million in the second quarter of 2018 and $0.96 million in the third quarter of 2017. The change in the third quarter of 2018 as compared to the second quarter of 2018 mainly derived from an increase in expenses related to business development in the third quarter of 2018, offset by a decrease in costs of share-based compensation.

Financial income for the third quarter of 2018 was $0.35 million, compared to financial income of $0.03 million in the second quarter of 2018. The increase was primarily due to changes related to fair value of the tradable and non-tradable warrants issued in prior fundraisings.

Net loss for the third quarter of 2018 was $1.9 million, or $0.014 per share and $0.29 per ADS, compared to $1.6 million, or $0.013 per share and $0.25 per ADS, in the second quarter of 2018, and $2.2 million, or $0.019 per share and $0.39 per ADS, in the third quarter of 2017.

Balance Sheet Highlights:

Cash and cash equivalents and marketable securities totaled $6.45 million as of September 30, 2018, compared to $8.26 million on June 30, 2018, and $7.6 million on December 31, 2017. The change in the cash and cash equivalents and marketable securities was primarily due to net proceeds of $3.5 million from a registered direct offering completed in January 2018, offset by cash used in operations during the period.

Shareholders’ equity totaled $4.5 million as of September 30, 2018, compared to $6.1 million on June 30, 2018, and $5.2 million on December 31, 2017.

Stock influences and Risk factors

Continued affirmation of the company’s stem cell process could be a catalyst for the company shares.

Competition in the biotech sector is strong and the company may lose forward momentum if a competitor has better research.

The company relies on funding from public offering that may dilute the value of the shares.

Stock chart

On Monday, March 11, 2019, APOP shares were at $1.23 on traded volume of 5.4 million shares. The current RSI (14) is 43.63

At $1.23, APOP shares are trading below their 50 DMA and 200 DMA of $1.94 and $4.50 respectively.

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