Stem cell regenerative therapies, for a variety of indications, are at the leading edge of biopharma technology. The science in stem cell research has advanced significantly over the past decade, and now billions of stem cells can be replicate from a single human donor cell. But the stigma of stem cells being taken from human embryos still hangs over the sector by the uninformed.
The companies involved in developing stem cell therapied present an opportunity for investors as many of them are still undervalued yet have products in clinical trials that if/when approved by the FDA could cause their values to explode and I want to look at a couple.
iSpecimen Inc. (NASDAQ: ISPC) offers an online marketplace for human biospecimens, connecting scientists with healthcare providers that have access to patients and specimens needed for medical discovery.
When labs working on stem cell therapies need that human donor stem cell to replicate, how do they get it? They could go online and order it from ISPC. They have the stem cell products biopharma researchers need that contain primary cells utilized in autoimmune and infectious disease research, drug discovery and preclinical development, such as:
Hematopoietic stem cells (HSCs or CD34+): oligopotent stem cells that give rise to each mature blood cell type.
Mesenchymal stem cells (MSCs): in unprocessed whole bone marrow aspirate (bone marrow stromal stem cells), multipotent stem cells capable of differentiating into osteoblasts, myocytes, adipocytes, chondrocytes; MSCs also possess immunomodulatory function
Immune cells: Pan T (CD3+), Helper T (CD4+), Cytotoxic T (CD8+), NK (CD 56+), B cells (CD 19+), Monocytes (CD14+), antigen presenting cells (dendritic), neutrophils, macrophages, and related cell types.
ISPC has a tiny share structure, $10M (ttm) revenues, and a market cap at only $18M. Investors may want to consider this unique player in the stem cell biopharma sector.
Athersys, Inc. (NASDAQ: ATHX) has seven clinical trials in progress to treat ischemic stroke, acute respiratory distress syndrome, and trauma based upon their unique MultiStem Cell Therapy (invimestrocel) derived from the bone marrow of healthy, consenting adult donors.
ATHX is currently in a Phase 3 clinical trial being conducted primarily in North America and Europe to treat ischemic stroke. The trial falls under an FDA Special Protocol Assessment, or SPA. In addition, this program received the Fast Track designation, as well as the Regenerative Medicine Advanced Therapy, or RMAT, designation from the FDA. The company is also involved in a preclinical study for the Department of Defense to determine the regenerative efficacy of their product to treat radiation exposure.
The company completed a 25 for 1 reverse stock split in late August reducing its outstanding share count to 12M and is currently negotiating a $12M capital raise with a private institutional investor that specializes in healthcare companies.
Update: New Report 9-26-22 Grom Social (NASDAQ: GROM) May be on the verge of a deal with streaming service like $DIS, $NFLX, $HULU or $AMZN – FULL REPORT HERE
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